Making progress on Alzheimer's
Over the last week scientists from around the world have gathered in Paris to share news and research and discuss the future of a disease that directly affects 750,000 of us in the UK alone. At the moment Alzheimer’s disease is hard to detect at its early stages, and as yet there is no cure for it. So is there anything positive to say?
"The good news out of the Alzheimer’s International Conference this year is that we are making advances towards earlier detection of Alzheimer’s," said William Thies, PhD, Alzheimer’s Association Chief Medical and Scientific Officer.
"These advances are critical to helping people live longer, healthier lives free of the disability and death caused by Alzheimer’s. Identifying the disease early in its process – even before symptoms start to become evident – and treating it early is how we will accomplish that."
Falling is one potential early sign of Alzheimer’s disease. Research carried out at Washington University, St Louis, USA, found that people with the earliest signs of this disease are more likely to have a fall. The study looked at a group of older people with healthy cognitive (thinking) ability, some of whom had preclinical Alzheimer’s. (This was measured using positron emission tomography (PET).) The results showed that those with the highest marker for Alzheimer’s had twice the risk of falling.
"Understanding the traditional hallmarks of Alzheimer’s, including cognitive impairment and memory loss are important; however, these study results also illustrate the significance of understanding that, in some people, changes in gait and balance may appear before cognitive impairment," said Maria Carrillo, PhD, Alzheimer’s Association Senior Director of Medical and Scientific Relations.
Two studies carried out on different continents indicate that tests on blood and spinal fluid could be vital in new methods to detect Alzheimer’s disease before symptoms appear. The first study, from Perth in Australia, looked at blood samples and brain scans from 273 Alzheimer’s patients. It found nine markers in the blood which, when combined, were able to predict with an 88 % success rate whether someone would have a significant build-up of the protein amyloid in their brains, a sign of Alzheimer’s.
In the second study from Sweden, researchers checked the spinal fluid of 137 people with mild cognitive impairment (MCI), for the presence of two proteins (amyloid and tau). Their results showed that 90 % who had MCI and levels of these proteins that were high enough to detect, went on to develop Alzheimer’s within 10 years or less.
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At the moment Alzheimer's disease is hard to detect at its early stages, and as yet there is no cure for it. So is there anything positive to say? "The good news out of the Alzheimer's International Conference this year is that we are making advances
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